Scientific Evidence

IHHT and IHT research and publications

Research on the method and OXYTERRA resources are presented separately.

Publication library

Some publications are currently available only in Russian.

Hypoxic Adaptation and Aging: Tsyganova’s Review

Цыганова

Wellness and Prevention · Gerontology and healthy ageing · Review articles · Literature review

Hypoxic adaptation and aging: Tsyganova's author review of functional reserves, oxygen metabolism, and limits of rejuvenation claims.

Hypoxic training, sleep apnea, and aging markers: a review

Tessema · 2022

Gerontology and healthy ageing · Mitochondrial Medicine · Review articles · Systematic review

Hypoxic training, sleep apnea, and aging: a systematic review of 38 studies, biomarkers, clinical measures, and the absence of evidence for life extension.

Source

IHHT after infarction in older adults: a 2026 dissertation

Андреева · 2026

Gerontology and healthy ageing · Cardiometabolic Health · Review articles · Rehabilitation and Recovery · Clinical study

IHHT after infarction in older adults: a dissertation on 102 patients, two-week cardiac rehabilitation, exercise tolerance, and limitations of short follow-up.

Six weeks of IHHE in older adults: a 2026 study

Ladriñán-Maestro · 2026

Gerontology and healthy ageing · Cardiometabolic Health · Review articles · Clinical study

Six-week IHHE in older adults: a randomized study of respiratory function, blood pressure, heart rate variability, and CRP. Mixed results and PDF.

Source

IHT and exercise tolerance in older men: a 2004 study

Burtscher · 2004

Gerontology and healthy ageing · Cardiometabolic Health · Review articles · Sports medicine · Clinical study

Intermittent hypoxia and exercise tolerance in men aged 50–70 with and without coronary artery disease: a placebo-controlled 2004 study, limitations, and PDF.

Source

IHHT in mild cognitive impairment: a 2019 pilot study

Serebrovska · 2019

Gerontology and healthy ageing · Mitochondrial Medicine · Review articles · Clinical study

IHHT in mild cognitive impairment: a pilot study of 21 participants, cognitive tests, and circulating biomarkers. Limits of the conclusions and PDF.

Source

IHHT in aesthetic and age management medicine: a review

Кардашова

Wellness and Prevention · Gerontology and healthy ageing · Review articles · Literature review

IHHT in aesthetic and age management medicine: mechanisms, the authors' observations of skin microcirculation, and limitations of anti-aging claims. PDF.

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The resources in this section are provided for professional reference and do not constitute medical advice. Decisions on use of the method, procedure parameters and possible restrictions are made by a qualified practitioner, taking account of the user’s condition and the legal requirements of the country concerned.

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