IHHT after myocardial infarction was assessed in a randomized study of 77 patients. The abstract reports echocardiography and six-minute walk test results.
Editor’s note. The title uses the general term ‘hypoxic’, but the methods explicitly describe intermittent hypoxic-hyperoxic training, or IHHT. This is a brief conference abstract; it does not allow a full assessment of safety or long-term outcomes. Adjacent abstracts are not included. Below is a detailed English editorial exposition of the supplied Russian-language publication. It is not a verbatim reproduction; it preserves the source data and attribution. Tables and illustrations are available in the unchanged original PDF. This is scientific material, not treatment guidance.
Publication at a glance
- The authors allocated 77 patients following non-Q-wave infarction using the envelope method. The IHHT group included 40 participants, and the group without IHHT included 37.
- The authors assessed echocardiographic findings and six-minute walking distance.
- The study used ReOxy; its results do not constitute a trial of the OXYTERRA RS device.
IHHT after myocardial infarction: published findings
Objective
The objective was to investigate the effect of intermittent hypoxic-hyperoxic training (IHHT) on intracardiac hemodynamics. The authors studied rehabilitation during the subacute phase after non-Q-wave myocardial infarction (MI).
Materials and methods
The authors examined 77 patients with subacute non-Q-wave MI and chronic heart failure of NYHA functional class II–III. Mean age was 61.4±4.2 years. All had undergone stenting of one or more coronary arteries 14–16 days before training. Patients were allocated to two groups using the envelope method. The first included 40 participants. In the wording of the abstract, they received ’15 IHHT sessions in two courses separated by 1 month’ using the ReOxy device (Germany).
The second group, comprising 37 patients, did not receive IHHT. The groups were comparable in age, sex, and background therapy. A separate control group comprised 25 healthy individuals. Efficacy was assessed using the 6-minute walk test and echocardiography. Echocardiographic measurements included left ventricular (LV) linear dimensions, volumes, and myocardial mass index (LVMI).
Results
The authors noted clinical improvement with the addition of IHHT. The 6-minute walking distance increased by 40.9% with IHHT and by 28% without it (p<0.05 in both cases). The difference relative to the group without IHHT was 13.7% (p<0.05). In the IHHT group, LV end-diastolic volume (EDV), end-systolic volume (ESV), and LVMI decreased by 14%, 19.4%, and 11.6%, respectively (p<0.05). EDV and ESV were 12.4% and 16.2% lower than in the group without IHHT (p<0.05). Ejection fraction also increased by 12.2% (p<0.05). Without IHHT, however, the authors observed only a trend toward changes in intracardiac hemodynamics.
Conclusion
The authors concluded that rehabilitation with IHHT had a greater effect on myocardial remodeling than treatment without it. They described significant reductions in LV EDV, ESV, and LVMI, and an increase in ejection fraction. They also noted a statistically significant improvement in exercise tolerance.
Original publication data
Complete tables, illustrations, and the authors’ original wording are available in the source PDF. The links below open the corresponding pages of the original.
Abstract: IHHT after non-Q-wave infarction, original, page 3
Technology and applications
The publication concerns a specific course of IHHT within a rehabilitation program. The session principle is described in the section on IHHT technology. Modes and controls are described on the page for the OXYTERRA RS device.